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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PKLR
All Species:
31.52
Human Site:
Y517
Identified Species:
57.78
UniProt:
P30613
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30613
NP_000289.1
574
61830
Y517
R
G
V
F
P
L
L
Y
R
E
P
P
E
A
I
Chimpanzee
Pan troglodytes
XP_524896
538
57768
S485
G
R
S
A
Q
L
L
S
R
Y
R
P
R
A
A
Rhesus Macaque
Macaca mulatta
XP_001112902
720
77465
Y663
R
G
V
F
P
L
L
Y
R
E
P
P
E
A
I
Dog
Lupus familis
XP_547547
574
62029
Y517
R
G
V
F
P
L
L
Y
S
E
P
P
E
A
I
Cat
Felis silvestris
Mouse
Mus musculus
P53657
574
62290
Y517
R
G
V
F
P
L
L
Y
R
E
P
P
E
A
V
Rat
Rattus norvegicus
P12928
574
62182
Y517
R
G
V
F
P
L
L
Y
R
E
P
P
E
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P00548
530
57996
C473
R
G
V
F
P
V
L
C
K
Q
P
A
H
D
A
Frog
Xenopus laevis
Q92122
527
57507
Y470
R
G
I
F
P
V
L
Y
R
E
A
V
H
E
A
Zebra Danio
Brachydanio rerio
NP_955365
532
58039
Y475
R
G
I
F
P
I
Y
Y
N
S
P
S
N
D
V
Tiger Blowfish
Takifugu rubipres
NP_001027734
531
58206
Y474
R
G
I
F
P
V
L
Y
T
K
P
S
N
D
V
Fruit Fly
Dros. melanogaster
O62619
533
57422
Y476
R
G
L
V
P
L
I
Y
K
E
P
G
L
G
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P52489
506
55177
G455
P
K
R
L
D
D
W
G
E
D
V
H
R
R
L
Red Bread Mold
Neurospora crassa
Q7RVA8
527
57852
F457
R
G
V
Y
P
F
L
F
P
E
S
K
P
D
F
Conservation
Percent
Protein Identity:
100
92.6
78.1
92.5
N.A.
91.6
91.1
N.A.
N.A.
64.8
66.3
64.6
65.8
54.5
N.A.
N.A.
N.A.
Protein Similarity:
100
93.2
78.8
95.6
N.A.
95.4
95.1
N.A.
N.A.
78
78.9
78.2
78.4
70.2
N.A.
N.A.
N.A.
P-Site Identity:
100
33.3
100
93.3
N.A.
93.3
100
N.A.
N.A.
46.6
53.3
40
46.6
46.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
100
93.3
N.A.
100
100
N.A.
N.A.
66.6
66.6
60
73.3
66.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
45.9
45.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
61.1
62
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
40
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
8
8
0
47
24
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
0
0
0
8
0
0
0
31
8
% D
% Glu:
0
0
0
0
0
0
0
0
8
62
0
0
39
8
0
% E
% Phe:
0
0
0
70
0
8
0
8
0
0
0
0
0
0
8
% F
% Gly:
8
85
0
0
0
0
0
8
0
0
0
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
16
0
0
% H
% Ile:
0
0
24
0
0
8
8
0
0
0
0
0
0
0
31
% I
% Lys:
0
8
0
0
0
0
0
0
16
8
0
8
0
0
0
% K
% Leu:
0
0
8
8
0
54
77
0
0
0
0
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
16
0
0
% N
% Pro:
8
0
0
0
85
0
0
0
8
0
70
47
8
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
85
8
8
0
0
0
0
0
47
0
8
0
16
8
0
% R
% Ser:
0
0
8
0
0
0
0
8
8
8
8
16
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
54
8
0
24
0
0
0
0
8
8
0
0
24
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
70
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _